Competition of Polyvinylpyrrolidone and þ- cyclodextrin in association with different surfactants

Souri, M. and Rafati, A. A. (2008) Competition of Polyvinylpyrrolidone and þ- cyclodextrin in association with different surfactants. In: 11th Iranian Physical Chemistry Seminar-July 2008, July 2008, Ardabil, Iran.

[img] Text
3.pdf

Download (14kB)
Official URL: http://uma.ac.ir/

Abstract

Cyclodextrins (CDs) are cyclic oligosaccharides consisting of several glucose units linked by R-1,4 glycoside bonds[1]. These systems possess a toroidal or hollow, truncated cone shape with a nonpolar, hydrophobic interior and two hydrophilic rims formed by the primary and secondary OH groups (narrower and wider rim, respectively). By virtue of their unusual structure, CDs can form inclusion complexes through noncovalent interactions with molecules of specific size, shape, and polarity[2]. The ability of these systems to modulate reactivity depends on their capacity to complex organic substances. Changes in physicochemical properties and reactivities result from such host-guest interactions[3]. The effects that the formation of inclusion complexes has on reactivity vary widely depending on the guest, the CD, and the reaction. In some cases, the reaction rate is greatly reduced, which has led to the use of CDs as stabilizers; but of more interest are the situations in which CDs accelerate reactions. Moreover, the CDs may even participate directly in the reaction[4]. Because of ability of cyclodextrins to form inclusion complexes with hydrophobic drug molecules, their main applications have been to enhancing the solubility and dissolution of dugs, but studies have also shown that the stability and bioavailabilty of the guest drugs can sometimes be increased[5,6,7]. Poly(vinylpyrrolidone) (PVP) is an amphiphilic polymer and will readily dissolve in water and many nonaqueous solvents[8]. It finds widespread application in a number of areas, for example, in aerosol products such as hair sprays, in glues, as a complexing agent for dyes to impart solubility, as a dispersing agent to provide colloid stability, and also as a blood plasma substitute[9]. It has been shown that PVP is able to inhibit protein adsorption onto surfaces. For example, the coating of filtration membranes with PVP has been found to reduce fouling by bovine serum albumin (BSA)[10,11] and lysozyme[12]. Both PVP and cyclodextrin can interact with hydrophobic chain of surfactants. In this work we study the Competition of poly vinyl pyrolidon and þ- cyclodextrin in association with surfactants having different chain length. Results show that surfactants that have the longer chain form more stable complexes with cyclodextrin. In addition PVP compete with cyclodextrin on interaction with surfactant, therefore at presence of PVP binding constant of cyclodextrin- surfactant complex decreases.

Item Type: Conference or Workshop Item (Paper)
Persian Title: Competition of Polyvinylpyrrolidone and þ- cyclodextrin in association with different surfactants
Persian Abstract: Cyclodextrins (CDs) are cyclic oligosaccharides consisting of several glucose units linked by R-1,4 glycoside bonds[1]. These systems possess a toroidal or hollow, truncated cone shape with a nonpolar, hydrophobic interior and two hydrophilic rims formed by the primary and secondary OH groups (narrower and wider rim, respectively). By virtue of their unusual structure, CDs can form inclusion complexes through noncovalent interactions with molecules of specific size, shape, and polarity[2]. The ability of these systems to modulate reactivity depends on their capacity to complex organic substances. Changes in physicochemical properties and reactivities result from such host-guest interactions[3]. The effects that the formation of inclusion complexes has on reactivity vary widely depending on the guest, the CD, and the reaction. In some cases, the reaction rate is greatly reduced, which has led to the use of CDs as stabilizers; but of more interest are the situations in which CDs accelerate reactions. Moreover, the CDs may even participate directly in the reaction[4]. Because of ability of cyclodextrins to form inclusion complexes with hydrophobic drug molecules, their main applications have been to enhancing the solubility and dissolution of dugs, but studies have also shown that the stability and bioavailabilty of the guest drugs can sometimes be increased[5,6,7]. Poly(vinylpyrrolidone) (PVP) is an amphiphilic polymer and will readily dissolve in water and many nonaqueous solvents[8]. It finds widespread application in a number of areas, for example, in aerosol products such as hair sprays, in glues, as a complexing agent for dyes to impart solubility, as a dispersing agent to provide colloid stability, and also as a blood plasma substitute[9]. It has been shown that PVP is able to inhibit protein adsorption onto surfaces. For example, the coating of filtration membranes with PVP has been found to reduce fouling by bovine serum albumin (BSA)[10,11] and lysozyme[12]. Both PVP and cyclodextrin can interact with hydrophobic chain of surfactants. In this work we study the Competition of poly vinyl pyrolidon and þ- cyclodextrin in association with surfactants having different chain length. Results show that surfactants that have the longer chain form more stable complexes with cyclodextrin. In addition PVP compete with cyclodextrin on interaction with surfactant, therefore at presence of PVP binding constant of cyclodextrin- surfactant complex decreases.
Subjects: Divisions > Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Divisions: Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Subjects > Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Date Deposited: 17 Jun 2019 05:58
Last Modified: 17 Jun 2019 05:58
URI: http://repository.uma.ac.ir/id/eprint/6846

Actions (login required)

View Item View Item