Study on synergistic effect of some medicinal plants combination on diabetic rats

Bakhshi, Roodabeh and Bayrami, Abolfazl and Razavi, Mahdi and Malekzadeh, Vadoud (2016) Study on synergistic effect of some medicinal plants combination on diabetic rats. Masters thesis, university of Mohaghegh Ardabili.

Text (بررسی اثر سینرژیک چند گیاه دارویی به‌صورت ترکیبی بر درمان موش‌های دیابتی) Roodabeh Bakhshi.pdf Download (1MB)

Abstract

Diabetes is one of the most important endocrine diseases in the world, that a lot of people are infected to this diseases each year. The disease is caused by deficiency of insulin secretion from beta cells or caused by reducing tissue sensitivity to insulin. Due to the adverse effects of chemical drugs lowering blood sugar, try to use alternative medicines, such as herbal medicines will increase day to day. Due to a combination of antioxidant herbs (turmeric, cinnamon, vaccinium arctostaphylos , mulberry leaves and ginger), this study were performed to determine the effect of the extract synergistic on biochemical parameters in diabetic male rats were performed. In this experimental study, 45 Wistar rats were divided randomly into 9 groups of 5. The groups are: Healthy control, Diabetic control, Diabetes treated with 100 mg/kg metformin, Diabetes treated with 100 mg/kg cinnamon extract, Diabetes treated with 100 mg/kg turmeric extract, Diabetes treated with 100 mg/kg mulberry leaves extract, Diabetes treated with 100 mg/kg turmeric extract, Diabetes treated with 100 mg/kg(Vaccinium arctostaphylos extract, Diabetes treated with 100 mg/kg ginger extract and diabetic treated with the 100 mg/kg extract combination(with equally turmeric, cinnamon, vaccinium arctostaphylos, mulberry leaves and ginger). For induction of diabetes, alloxan injection was used. At the end, Fasting blood glucose, triglycerides, cholesterol, HDL-C, LDL-C, VLDL-C in the blood were measured. Datum was analyzed by ANOVA and SPSS at the significance level of p<0.05.In diabetic patients treated with combined extract -treated groups, extracts of turmeric, cinnamon, mulberry leaves, ginger and vaccinium arctostaphylos, a significant decrease in blood glucose, triglycerides, cholesterol, LDL-C, VLDL-C, was seen.Combined extract had positive effect on reducing risk factors in diabetes and in case of favorable clinical results, can be used as a medicine for diabetes treatment.

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