Study on effects of Zno nanoparticles prepared by extract of Artemisia absinthium on wound healling in rats

Sahmani Asl, Roghayyeh (2019) Study on effects of Zno nanoparticles prepared by extract of Artemisia absinthium on wound healling in rats. Masters thesis, University of Mohaghegh Ardabili.

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Abstract

Research Aim:Considering the positive effects of medicinal plants on controlling and treating diseases as well as the advancement of new sciences such as nanotechnology, it is possible to combine traditional science with new effective ways to control and treat diseases. In this study, the goal of helping treatment The wound is made using zinc oxide nanoparticles prepared with an extract of the plant. Hemmatium is a plant that reduces inflammation and antioxidants. Zinc oxide nanoparticles have antibacterial, anti-inflammatory and antiseptic properties that are widely used in the production of skin creams. Research method: In this study, the aqueous extract of the plant (Artemisia absinthium) was prepared. Zinc oxide nanoparticles were synthesized and prepared for use as an aqueous extract, and their effects on wound healing induced in mice were studied. Structural properties of nanoparticles were evaluated using XRD, TGA, UV-vis DRS, FT-IR, BET, and SEM analyzes. 4 Wistar rats group (n = 5 in each group) were treated. After wounding in the skin of mice, they were exposed to the extract and prepared nanoparticles for 18 days. Every three days the wound dressing was changed and imaged. Progressive changes in the wound area were recorded every six days and for 18 days .At the end of the 6th, 12th and 18th days,the wound specimen was sampled and subjected to Hematoxylin- Eosin and Mason staining Findings: was 19 nm, which showed a decrease in size relative to the oxidation nanoparticles synthesized by the chemical method (19.5 nm). Also, TGA, UV-vis DRS and FT-IR techniques confirmed the presence of plant extracts molecules with zinc oxide. The results showed a significant decrease in the size of the wound in the mice treated with the extract of the alumina extract than the control group. Conclusion: According to the results, we can conclude thatcombination of traditional and new science meaningful impact seems to make a great difference in accelerating wound healing.

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