Evaluation the effects of Cerium oxide nanoparticles on functional recovery of damaged motor and sensory neurons follwing crush of the sciatic nerve in rats

Soluki, Milad (2020) Evaluation the effects of Cerium oxide nanoparticles on functional recovery of damaged motor and sensory neurons follwing crush of the sciatic nerve in rats. Masters thesis, University of Mohaghegh Ardabili.

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Abstract

Research Aim: Following severe peripheral nerve injury (PNI), nerve regeneration and functional recover did not occur completely. The objective of the present study was to assess the effect of cerium oxide nanoparticles on functional recovery of sensory and motor neurons following sciatic nerve crash in male Wistar rats. Research method: Forty male Wistar rats were divided into five groups (n = 10 in each group) including intact control, negative control (Crush the nerve), sham-operated group (surgical procedure without the nerve crash), experimental group 1 and 2 (sciatic nerve was crashed and treated with 20 or 80 mg/kg cerium oxide nanoparticles respectively. Then, the right sciatic nerve was crashed one centimeter above the nerve branching site. The foot print test was evaluated during the test period. Findings: Regeneration process rate and functional recovery quality of sciatic nerve sensory and motor neurons significantly increased in rats treated with cerium oxide nanoparticles compared to negative control group. Conclusion: Administration of cerium oxide nanoparticles improve the regeneration process of sensory and motor neuron peripheral sensory and motor neuron injury in rats.

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