Survey on the effect of six weeks endurance training on heart tissue SOD and GPx resting levels of Wistar male rats with experimental diabetes

بلبلی, لطفعلی and خواجه لندی, مژده Survey on the effect of six weeks endurance training on heart tissue SOD and GPx resting levels of Wistar male rats with experimental diabetes. University of Mohaghegh Ardabili.

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Abstract

Antioxidant status of tissue changes in diabetes and increases membrane and tissue oxidative damage. Based on the possibly positive role of exercise training on antioxidant status, the aim of this study was comparing the effect of six weeks of endurance training on glutathione peroxidase and superoxide dismutase activity in cardiac tissue of healthy and diabetic Wistar rats. Then, 24 adult male rats were randomly divided into 4 groups of 6: diabetic training group (DT), diabetic control group (DC), healthy training group (HT) and healthy control group (HC). The animals performed 6 weeks of moderate-intensity endurance training. 24 hours after the last training session the heart tissues for measuring glutathione peroxidase and superoxide dismutase activity were extracted. Data were analyzed by one-way ANOVA test. After 6 weeks of endurance training, changes of glutathione peroxidase levels was significantly different in diabetic training group compare to healthy and diabetic control groups with significance levels of (P=0/007) and (P=0/017) respectively. The levels of superoxide dismutase also increased significantly in diabetic training compare to diabetic control group with significance level of (P=0/025). it seems that moderate-intensity endurance exercise may have a significant effect on the antioxidant system of diabetic rat heart tissue and it can be helpful in preventing the development of cardiovascular complications from diabetes.

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