Survey on the effect of swimming and melatonin supplementation on oxidative stress status in the cardiac tissue from diabetic rats induced by streptozotocin

Rahbarghazi, Afshin (2021) Survey on the effect of swimming and melatonin supplementation on oxidative stress status in the cardiac tissue from diabetic rats induced by streptozotocin. Doctoral thesis, University of Mohaghegh Ardabili.

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Abstract

Research Aim: The aim of this study was to survey on the effect of swimming and melatonin supplementation on oxidative stress status in the cardiac tissue from diabetic rats induced by streptozotocin. Research method: This study is an experimental and pre-test-post-test of 80 adult male mice weighing 25-30 g. The mice were randomly divided into five groups (n=10 per group) as follows: (I) Control (C); (II) Diabetic (DM) group; (III) Diabetic + Melatonin (DM + Met) group; (IV) Diabetic + Exercise (DM + Exc) group; and (V) Diabetic + Exercise + Melatonin (DM + Exc + Met) group. To induce diabetic condition, intraperitoneal injection of 50 mg/kg streptozotocin was performed. In melatonin-treated groups, melatonin was injected intraperitoneally at 3 mg/kg BW for four weeks and twice weekly. Swimming exercises were performed for four weeks and one hour per day for 3 days per week. After the completion of experiments, the levels of cardiac SOD, GPX, MDA, and TAC enzymes were measured. Findings: The results showed that a combination of exercise and melatonin increased the levels of cardiac enzyme SOD and GPx with decreasing MDA and also increased TAC levels compared to diabetic rats (P <0.05). Conclusion: These data demonstrated that exercise along with melatonin can reduce the harmful effects of diabetes via different mechanisms.

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