Survaey on the effect of short term silymarin supplementation on some of biochemical serum levels induced by one-bout aerobic exercise in active male after

Heidari, Behrouz and Siahkouhian, Marefat and Meamarbashi, Abbas (2015) Survaey on the effect of short term silymarin supplementation on some of biochemical serum levels induced by one-bout aerobic exercise in active male after. Masters thesis, University of Mohaghegh Ardabili.

Text (تأثیر مکمل‌دهی کوتاه‌مدت سیلی‌مارین(Silymarin) بر برخی از شاخص‌های زیست شیمیایی مردان فعال متعاقب يک جلسه فعالیت هوازی) Behrouz Heidari.pdf Download (999kB)

Abstract

Introduction: Silymarin is a kind of flavonolignan compound, it is extracted from the seeds of composite plant milk thistle. It has been suggested that silymarin has anti inflammatory and anti-oxidant properties and could be prevent of some undesirable biochemical indexes in patients and even athletes. The aim of this study was to determine the effect of short term silymarin supplementation on some of biochemical serum levels induced by one-bout aerobic exercise in active male after. Methods: In a semi-experimental, Twenty-two active male (mean age 25/09±2/11 years, body fat 13/56±1/94% and VO2max 50/5±4/88 ml/kg-1/min) were randomly divided into two equal (n=11) groups including supplement and placebo groups in a double-blind design: After 7-days of supplementation period (6 mg.kg-1.day silymarin or Dextrose) all subjects performed an aerobic exercise including running on the treadmill with 65-70% Heart rate Reserve for 30 min. Blood samples were taken at four phases (baseline, after supplementation period, immediately and 24 hours after the exercise) were determined for changes in the level of serum AST, ALT, ALP, CK and LDH. Data were analyzed by using of repeated measure of ANOVA, bonferroni and independent t tests at α≤0/05. Results: The results showed that the 7-days silymarin intake had no significant effect on the basal liver enzymes levels (P≥0.05). Moreover, 30 min aerobic exercise, the levels of serum liver enzymes significantly increased immediately and 24 hours after exercise in silymarin and Dextrose groups (P≤0.05). However, after 24 hours of aerobic exercise, all of liver enzymes activity increased significantly in dextrose group in comparison with silymarin group (P≤0.05). Conclusion: Based on the present findings, it seems that silymarin supplementation can inhibit aerobic exercise-induced biochemical indices in active male via enhancement of antioxidant and anti-inflammatory defense system of the body.

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