Effects of Caffeine Benzoat On th Electrical Conductivity of SA node and AVnode, and the study of its changes on PR interval and PR segment in normal Electrocardiograms .

Mahmoodi, Arjang and Masoomi, lotfali and Bayrami, abolfazl (2015) Effects of Caffeine Benzoat On th Electrical Conductivity of SA node and AVnode, and the study of its changes on PR interval and PR segment in normal Electrocardiograms . Masters thesis, University of Mohaghegh Ardabili.

Text (بررسی اثرات کافئین بنزوات بر هدایت الکتریکی SAnode و AVnode و مطالعه تغییرات حاصل از آن در PR segment و PR interval الکتروکاردیوگرام‌های نرمال .) Arjang Mahmoodi.pdf Download (235kB)

Abstract

: In our country, caffeine often are using in the form of oral to relieve fatigue, sleep; improve concentration, improve mental preparedness, while caffeine in the form of drug (caffeine citrate and caffeine sodium benzoate) is less studied. Caffeine is using as a combination of different drugs but so far it has not been done comparing the effects of edible and medicinal one. The aim of this study was to evaluate the effects of caffeine containing benzoic acid 3.5 mg/kg of caffeine (the optimum of caffeine oral) by tablet form on the heart's electrical conduction due to the changing in electrocardiography pattern. In recent study the effects of caffeine in sodium benzoate form in eighty healthy volunteer's student aged 20 to 30 that were not permanent caffeine consumers through food or drug has been investigated. In two group: placebo (control group) and caffeine benzoate treated group. The results showed that in the control group in any of the studied parameters were not significantly change before and after Placebo but in the caffeine benzoate treated group significantly Heart Rate parameter decrease from 71.13 b/m to 65.22 b/m. Decreased heart rate in relation to the increased levels of cAMP in the heart Myocyte by activating protein kinase A and subsequently increased sensitivity to calcium cardiomyocyte cause strong contraction and slow the heart. PR Segment parameter after the atrial contraction to guide electrical current from the sino atrial node to the atrioventricular node is necessary While the electrical conductivity of the sino atrial node and his bundle then his branch and later changed to Purkinje's fiber will be logged. Dipped significantly from (ms) 52.81 to (ms) 46.72. In these experiments observed prolongation of the PR Interval parameter 134.53 (ms) to 141.46 (mc). Due to the increasing duration of atrial contraction under the influence of caffeine. It also increases the amplitudeP from 0.0857 (mv) to 0.161 (mv) was seen as a result of an increase in atrial contractility was under the influence of caffeine benzoate.

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