Study on Effects of Some Metal Oxide Nanoparticles on Some Blood Parameters of Mice

Sheydaeei, Parvin and Bayrami, Abolfazl and Azizian-Kalandaragh, Yashar and Masomi, Lotfali (2016) Study on Effects of Some Metal Oxide Nanoparticles on Some Blood Parameters of Mice. Masters thesis, University of Mohaghegh Ardabili.

Text (مطالعه اثرات نانوذرات برخی اکسید های فلزی روی بعضی فاکتورهای خونی موش) Parvin Sheydaeei.pdf Download (1MB)

Abstract

Considering the development of nanotechnology and extensive use of nanoparticles in different fields of industry, there are concerns about their toxic effects on the environment and human health. they have unique chemichal and physical properties such as small size and large surface area. Nowadays, Titanium dioxide and Zinc oxide in the production of cosmetics, food additives, photocatalysts, water and wastewater treatment and … . In this study, 70 adult male mice BALB/c, were divided into four groups. Titanium dioxide nanoparticles and Zinc oxide nanoparticles (Concentrations of 50, 100 and 300 mg/Kg) separately and in combination were administered orally to mice for 14 days. Finally, hematological and serum parameters were studied in the collected blood samples. Hemoglobin and neutrophils at concentration of 300 mg/kg Titanium dioxide nanoparticles showed significant increases in comparison with the control group. On the other hand, red blood cells, platelets, hematocrit, lymphocytes, glucose and creatinine significantly decreased (p<0.05). WBC, hemoglobin, MCV and neutrophils at concentration of 300 mg/kg Zinc oxide nanoparticles showed significant increases. red blood cells, platelets, hematocrit, lymphocytes, glucose and creatinine significantly decreased (p<0.05). WBC, hemoglobin and neutrophils at concentration of 300 mg/kg ZnO and TiO2 nanoparticles showed significant increases. red blood cells, platelets, lymphocytes, glucose and creatinine significantly decreased (p<0.05). The findings showed that Titanium dioxide nanoparticles and Zinc Oxide Nanoparticles cause harmful effects to the hematological and serum parameters in mice in a dose-dependent way.

Actions (login required)

View Item