The effects of Vitamin E on spermatogenesis of busulfan-treated mice

Rohnavaz Lalelo, Fatemeh and Mirzapour, Tooba and Masoumi, Lotf Ali and Bayrami, Abolfazl (2016) The effects of Vitamin E on spermatogenesis of busulfan-treated mice. Masters thesis, university of Mohaghegh Ardabili.

Text (اثرات ویتامین E روی اسپرماتوژنز موشهای تیمار شده با بوسولفان) Fatemeh Rohnavaz Lalelo.pdf Download (878kB)

Abstract

Busolfan (Bu) is a chemotrapic drug for treatment of cancer. It manifests cyto-toxic effects in different organs in animals. In the present study, intraperitoneal injection of different dosege of Bu (35 and 40 mg/kg body weight) increased oxidative stress in mice testes during 30th day of post-treatment .The enzymatic activity of catalase (CT) were significantly decreased over the post-treatment phase in Bu-treated mice testes compared to controls. Following Bu treatment, a significant decrease in sperm count was observed. The purpose of the present study was to evaluate the effect of vitamins E supplementation on Bu-treated mice testes. Therefore, 40 mg/kg Bu-treated mice group were injected with vitamins E, to assess the effect of the vitamin in cytotoxicity and other manifestations. Supplementation of vitamin E (100 mg/kg body weight) to Bu-induced mice group declined oxidative stress, increased sperm count profile, depressed the percentage of sperm abnormality and increased the activity of antioxidant enzyme (Catalase).

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