Effects of caffeine optimal dose on the electrical conductivity of sinoatrial and atrioventricullar nodes of male gender

Barmaki, Maryam and Masoomi, Lotfali and Panahpour, Hamdollah (2015) Effects of caffeine optimal dose on the electrical conductivity of sinoatrial and atrioventricullar nodes of male gender. Masters thesis, University of Mohaghegh Ardabili.

Text (بررسی اثرات دوز بهینه کافئین بر قابلیت هدایت الکتریکی گره sinoatrial و atrioventricullar در قلب جنس مرد) Maryam Barmaki.pdf Download (720kB)

Abstract

The heart is one of the most important organs in the body of the man that their vita depende on the it's beat and any tissue and physiological damage disrupt it's health. Heart activity depende on electrical impulses that generated by electrical conduction system. It's task is create rhythmic impulses in orther that regular contractions of heart muscle and rapid conduction impulse in the whole of heart. This system is sensitive damage due to the heart desease, drugs and certain material.Everey disfunction of this system often make an abnormal rhythms in Electrocardiogram. Caffeine is one of the effective material on this system. Caffeine (1,3,7- methylxanthine), which is a stimulant material was found in coffee, tea, cocoa and et. Biochemical mechanism of caffeine in the body, including the release of intracellular calcium, inhibits the enzyme phosphodiesterase and the most likely of them is adenosine receptor antagonist. The purpose of this study was to investigate the effects of caffeine on the quality of the electrical conductivity between the sinoatrial and atrioventricullar nodes according to electrocardiographic changes, the change in PR segment. Sixty volunteers in two stages, before and after 45 minutes, 3.5 mg/kg caffeine, taken 12-leads electrocardiograms. In two stages heart rate, PR interval and PR segment measured by LG smart scanner model LSM and compared and analyzed by spss software and paired T-test. After intake of caffeine length of PR segment reduced significantly. The dose of 3.5 mg/kg of caffeine increases the speed of the electrical conductivity of the sinoatrial node to the AV node.

Actions (login required)

View Item