The effect of absence seizure on some biochemical and hematological parameters in serum and CSF in WAG/Rij rats

Vatandoust, Seyed Mahdi and Masoumi, Lotf Ali and Shahabi, Parviz (2014) The effect of absence seizure on some biochemical and hematological parameters in serum and CSF in WAG/Rij rats. Masters thesis, university of Mohaghegh Ardabili.

Text (اثر صرع کوچک بر روی برخی از فاکتورهای بیوشیمایی و هماتولوژیکی در مایع مغزی-نخاعی و خون رتهای صرعی WAG/Rij) Seyed Mahdi Vatandoust.pdf Download (322kB)

Abstract

Epilepsy is a common neurological disorder that affects about one percent of the world population. There are several different types of seizures that Absence seizure is on of types which affects the S1po area in the brain cortex. In absence seizure attacks loses consciousness for a short time seen without seizures or falls or seen Aura. And common type of seizure in children. When absence seizures occur, patient was pale, his eyes staring at one point and he unaware of his surroundings. It is even possible for a very short period of time and not be visible. One factor that plays an important role in the pathogenesis of epilepsy, is change in the amount of biochemical and hematological parameters in blood and CSF. Brine osmolality and homeostasis is the important for brine function and ion balance adjustment is a critical process that involves complex processes for entry and exit of ions. Changes in this environment caused changes in osmolality and homeostasis that caused the exacerbated or backgrounds to the occurrence of many diseases, including epilepsy. In this study, we tried to evaluated the change of number of electrolytes, lipid profile in the blood and cerebrospinal fluid such as sodium, potassium, calcium, chloride, glucose, cholesterol, LDL, HDL, triglycerides and oxidative stress changes as GPX , MDA, SOD, TAC in wistar and epileptic WAG/Rij rats. This study showed that the level of electrolytes such as sodium, potassium and chloride in patients with epilepsy increased and calcium level is decreased٫ and level of lipid profile in WAG/Rij rats are decreas. It was found that levels of antioxidants such as as GPX ,SOD, TAC in epileptic WAG/Rij rats is low and the level of MDA is increase compared with control rats.

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