Studies on Anti-Diabetic Effects of Zinc Oxide (ZnO) Nanoparticles Prepared by Mary Thistle (Silybum marianum) in Diabetic Rats

Mohammadi Arvanagh, Farid (2017) Studies on Anti-Diabetic Effects of Zinc Oxide (ZnO) Nanoparticles Prepared by Mary Thistle (Silybum marianum) in Diabetic Rats. Masters thesis, University of Mohaghegh Ardabili.

Preview

Text (بررسی اثرات ضد دیابتی نانوذره اکسید روی (ZnO) تهیه شده با عصاره گیاهی خارمریم (Silybum marianum) بر روی موش های دیابتی شده) Farid Mohammadi Arvanagh.pdf Download (1MB) | Preview

Abstract

Nanotechnology is a discipline of applied science and technology that covers a wide range of topics. The advancement and efficiency of green synthesis is the use of natural reducers, stabilization of final materials without the use of toxic agents, the lack of use of expensive chemicals and lack of high energy consumption. Milk thistle as a potent inhibitor of lipoprotection reduces blood glucose. Diabetes is a chronic disorder in the metabolism of carbohydrates, fat and proteins, and its specificity is the increase in blood sugar in the patient. Cardiovascular failure, renal failure, and decreased neurological activity are the long-term complications of the disease. Zinc (Zn) is a necessary micronutrient in association with more than 300 types of enzymes and plays a key role in diverse biological processes, including glucose metabolism. In this study, ZnO nanoparticles were synthesized by chemical and biological methods using aqueous extract of S.marianum, and their anti-diabetic effects on diabetic rats with alloxan monohydrate and antibacterial effects of these nanomaterials on E.coli ,were investigated. Structural properties of nanoparticles were investigated using XRD, EDX, TGA, UV-vis, FT-IR, BET, SEM and TEM analyzes. The size of nanoparticles synthesized by biochemical methods, 19.9 nm, was determined to decrease the size of the nanoparticles synthesized by the chemical method (22 nm). Also TGA, UV-vis DRS and FT-IR techniques confirmed the presence of plant extract molecules with zinc oxide. Injection dose was determined for groups receiving nano-materials, 10 mg / kg body weight. Blood samples were taken on day 0, 4, 8, 12 and 16, and glucose samples were taken on the same days. The results indicate a significant reduction in fasting blood sugar in the recipient group of bioavailable nanoparticles compared to the control group (p<0.05). The ZnO nanoparticle at 0.8 mg / ml has the highest antibacterial properties.

Actions (login required)

View Item