Binding of sodium salt of cobalt phthalocyanine tetrasulfunated with calf thymus DNA: A thermodynamic approach

Afandak, A. and Sohrabi, N. and Bordbar, A. K. (2008) Binding of sodium salt of cobalt phthalocyanine tetrasulfunated with calf thymus DNA: A thermodynamic approach. In: 11th Iranian Physical Chemistry Seminar-July 2008.

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Abstract

Photosensitized reactions of molecular oxygen have recently found far-reaching applications in biology and medicine. Photodynamic therapy(PDT) of cancer is based on the tumor-specific accumulation of a phtosensitizer, often a porphyrin derivative, follwed by irradiation with visible light, which induces cell death and tumor ablation. PhotofrinR was the first phtosenstizer approved for human use, and has been successfully employed in the treatment of many types of tumor, including lung esophageal, cervical, bladder and gastric tumors. The change of photophysical properties can be a useful tool for getting information on the topology of binding sites and on the nature of interactions by which they were evoked[1,2]. In this work the interaction of a phthalocyanine complex as a anticancer drug analogue, with calf thymus DNA was studied using UV/Vis and fluorescence techniques.

Item Type: Conference or Workshop Item (Poster)
Persian Title: Binding of sodium salt of cobalt phthalocyanine tetrasulfunated with calf thymus DNA: A thermodynamic approach
Persian Abstract: -
Subjects: Divisions > Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Divisions: Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Subjects > Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Date Deposited: 17 Jun 2019 04:54
Last Modified: 17 Jun 2019 04:54
URI: http://repository.uma.ac.ir/id/eprint/6782

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