Metal Influence on the Histidine Acidity

Tavasoli, Elham and Fattahi, Alireza (2008) Metal Influence on the Histidine Acidity. In: 11th Iranian Physical Chemistry Seminar-July 2008.

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Abstract

Histidine is often found as a ligand in metalloenzymes.8,9 The imidazole side group has two nitrogen atoms capable of being participated in metal binding. Hence, histidine can take on various metal-bound forms. Alkali metal ions such as Na+, K+ and to a lesser extent Li+ are so important in living organism. They have significant role in structure stability and reactivity of biomolecules.11,12 Based on theoretical studies, it appeared that the positions of metal ion binding sites play critical roles in determining the location of bond formations and disruptions in biochemical process. 13 In this paper, we have carried out a detailed study on a) the coordination modes and geometrical structures; b) binding energies of the complexes formed by Li+, Na+, K+ ions with different active sites in histidine; c) gas phase absolute metal ion affinities of histidine and its zwitterionic form; d) acidity of imidazole and carboxylic sites and the influence of metal ions on these two acidic sites.

Item Type: Conference or Workshop Item (Poster)
Persian Title: Metal Influence on the Histidine Acidity
Persian Abstract: -
Subjects: Divisions > Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Divisions: Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Subjects > Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Date Deposited: 17 Jun 2019 04:54
Last Modified: 17 Jun 2019 04:54
URI: http://repository.uma.ac.ir/id/eprint/6783

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