Spectroscopic characterization and DFT calculations on the Structure of Biotin

Emami, Mohammad and Teimouri, Abbas and Najafi, Ali Reza Spectroscopic characterization and DFT calculations on the Structure of Biotin. In: 11th Iranian Physical Chemistry Seminar-July 2008, July 2008, Ardabil, Iran.

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Abstract

The vitamin H (biotin) is a ubiquitous prosthetic group of carboxylase and transcarboxylase enzymes [1, 2]. The action of biotin as the prosthetic group in carboxylating, trans and decarboxylating enzymes is standard textbook knowledge [3]. Biotin is the prosthetic group of biotin-dependent enzyme complexes, which catalyse key metabolic reactions. Biotin is attached by covalent amide linkage to the N6-amino group of a specific lysine residue, and acts by shuttling CO2 between the di¡erent active sites in these enzyme complexes [4]. We have recently reported the DFT calculation of the 4-substituted aminoazo-benzenesulfonyl azides [5] and a series of azo dyes derived from 2-Hydroxy and 2, 4-Dihydroxy benzoic acids [6] and azoic dyes with sulfonyl azide group [6].

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