Investigation of interaction of a water-soluble cationic porphyrin, meso-tetrakis (tetrafluoro trimethyl ammonium) phenyl porphinato nickel acetate with calf thymus DNA

Fateminasab, F. and Sohrabi, N. (2008) Investigation of interaction of a water-soluble cationic porphyrin, meso-tetrakis (tetrafluoro trimethyl ammonium) phenyl porphinato nickel acetate with calf thymus DNA. In: 11th Iranian Physical Chemistry Seminar-July 2008, July 2008, Ardabil, Iran.

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Abstract

The interaction of water-soluble cationic porphyrins with DNA has been intensely studied due to its potential applications, which include probing for the structure and dynamics of nucleic acids, photodynamic therapy1, cancer detection2, virus inhibition, and artificial nucleases via their interaction with DNA. For these potential applications, understanding the exact binding mode of porphyrin to DNA is essential. The mode of binding depends on many factors: the number and positions of positive charges in the porphyrin molecule, ionic strength, amount ratio of porphyrin and the base-pair, and the porphyrin geometry. In this work the binding of meso-tetrakis (tetrafluoro trimethyl ammonium) phenyl porphinato Nickel (II) acetate, Ni(TF4TMAP) to calf thymus DNA has been studied in view of thermodynamic using UV/Vis spectroscopy. The physicochemical properties of Ni (TF4TMAP) were investigated in 5mM phosphate buffer, pH 7.0 at various environmental conditions.

Item Type: Conference or Workshop Item (Paper)
Persian Title: Investigation of interaction of a water-soluble cationic porphyrin, meso-tetrakis (tetrafluoro trimethyl ammonium) phenyl porphinato nickel acetate with calf thymus DNA
Persian Abstract: -
Subjects: Divisions > Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Divisions: Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Subjects > Conferences > 11th Iranian Physical Chemistry Seminar- July 2008
Date Deposited: 17 Jun 2019 05:41
Last Modified: 17 Jun 2019 05:41
URI: http://repository.uma.ac.ir/id/eprint/6832

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