The Effect of Eight Weeks of Endurance Training and Low Calorie Diet on Some Cardiovascular Risk Factors in Men with Non-Alcoholic Fatty Liver Disease

Mahmoudi, Asghar and Siahkouhian, Marefat and Iranparvar Alamdari, Manouchehr and Seifi, Farnaz and Anari, Hassan (2018) The Effect of Eight Weeks of Endurance Training and Low Calorie Diet on Some Cardiovascular Risk Factors in Men with Non-Alcoholic Fatty Liver Disease. Post-Doctoral thesis, University of Mohaghegh Ardabili.

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Abstract

Background & objectives: Non-alcoholic fatty liver disease is the most common chronic liver disease in the world associated with cardiovascular diseases. The aim of this study was to investigate the the effect of eight weeks of endurance training and low calorie diet on some cardiovascular risk factors in men with non-alcoholic fatty liver disease. Methods: In this quasi-experimental study, 41 patients with non-alcoholic fatty liver disease (available) were selected and randomly assigned into 4 groups, endurance training group (n=10), interaction of endurance training with low calorie diet group (n=11), Low calorie diet group (n=10) and control group (n=10). The endurance training program included moderate intensity training with 55-75% of maximal heart rate for 45 min/session, 3 times/week for 8 weeks. Low calorie diet program was designed with a deduction of 500 kilocalories from the average calculated energy from a 3-day diet. Before the intervention and at the end of the eighth weeks, serum levels of Resistin, Chemerin, Homocysteine and Pentraxin-3 of participants were measured. One way Covariance analysis and Bonferrony post hoc test were used to extract the results (p<0.05). Results: Serum levels of Resistin decreased significantly in the endurance training group (p=0.002), interaction of endurance training and low calorie diet group (p=0.001) and low calorie diet group (p=0.004). In addition, the serum levels of Chemerin decreased significantly in the endurance training group (p=0.007) and interaction of endurance training and low calorie diet group (p=0.001). Also, serum levels of Homocysteine decreased significantly in the endurance training group (p=0.003) and interaction of endurance training and low calorie diet group (p=0.001). However, the serum levels of Pentraxin-3 increased significantly in the endurance training group (p=0.02) and interaction of endurance training and low calorie diet group (p=0.001). Conclusion: Probably, the interaction of endurance training with low calorie diets by decreasing serum levels of Resistin, Chemerin, Homocysteine and increasing serum levels of Pentraxin-3, may reduce risk factors and cardiovascular complications associated with non-alcoholic fatty liver disease.

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