Studies on anti_diabetic effects of Zinc oxide nanoparticles prepared by leaf extract of Nasturtium officinale in diabetic rats

Ghorbani, Elham and Bayrami, Abolfazl and Habibi Yangjeh, Aziz and Rahim Pouran, Shima (2019) Studies on anti_diabetic effects of Zinc oxide nanoparticles prepared by leaf extract of Nasturtium officinale in diabetic rats. Masters thesis, University of Mohaghegh Ardabili.

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Abstract

Research Aim:The aim of this study was to investigate the antidiabetic effect of zinc oxide nanoparticles synthesized by aqueous extract of Nasturtium officinale in diabetic rats. Research method:In this study, 30 male rats were divided into six groups of five: control group, diabetic control, insulin with a dose of 10 U/kg, ZnO synthesized by chemical method at a dose of 8 mg/kg, plant extract with a dose of 150 mg/kg and ZnO bioavailable at a dose of 10 mg/kg. For induction of diabetes, intraperitoneal injection of alloxan was administered at a dose of 150 mg per kg body weight. Structural properties of nanoparticles were investigated using XRD, EDX, TGA, UV-vis DRS, FT-IR, BET, SEM, and TEM analysis. Blood samples were taken from 0, 4, 8, 12 and 16 days of the injection, and glucose samples were checked out at the same days. Also serum cholesterol, triglyceride, HDL, LDL and insulin levels were measured on day 17, with a significant level of P<0.05. Findings: The results of the synthesized nanoparticle analysis indicate the presence of zinc and oxygen in both samples and the presence of organic compounds in bio-synthesized nanoparticles. Conclusion:The results showed a significant decrease in fasting blood glucose, total triglyceride and total cholesterol, as well as a significant increase in HDL and insulin levels in synthesized nanoparticles compared to diabetic control group.

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