The effect of sulfur-supplementation on aerobic strenuous exercise-induced inflammation and oxidative stress.

Zahra, Niknam and Nakhostin Roohi, Babak and Bohlooli, Shahab (2009) The effect of sulfur-supplementation on aerobic strenuous exercise-induced inflammation and oxidative stress. Other thesis, University of Mohaghegh Ardabili.

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Abstract

Exercise induces changes in several organs and tissues, and this process might be due to inflammation and oxidative damage caused by free radicals and inflammatory mediators. Aim: The purpose of this study was to examine the effect of sulfur-supplementation on exercise-induced inflammation and oxidative stress markers. Method: Sixteen untrained, healthy male (age: 20.35±1.35Yrs, height: 170.9±5.22 cm & weight: 70.60±8.06 kg) were randomly assigned to treatment (T) and placebo (P) groups. Blood samples were taken 2h and immediately before, immediately, 2h and 24h after exercise. Following the first sampling, the T and P groups supplemented 100 mg/kg of body weight Methylsulfonylmethane (MSM) and placebo, respectively. Subjects ran for 45 minutes with speed equal 75%VO2max and allowed to exhaustion on treadmill. C-reactive protein (CRP) by Neflometry, Malondealdehyde (MDA) by HPLC, Total Antioxidant capacity (TAC) and Lactatedehydrogenase (LDH) by Spectrophotometry were measured. Data were analyzed using repeated measures analysis of variance (ANOVA) with Bonferoni correction and t student. Results: There were no significant differences between two groups in CRP and LDH but there were significant differences in MDA at immediately before and 2h after exercise and in TAC at 24h after exercise (P<0.05).Conclusions: Although acute supplementation of MSM has not shown significant effect on inflammation via CRP but it may has effect on reduction of oxidative stress.

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