The study of sedative and anxiolytic effects of Plantago major leaf extract in rat

مجتهدین, علی (2015) The study of sedative and anxiolytic effects of Plantago major leaf extract in rat. University of Mohaghegh Ardabili, University of Mohaghegh Ardabili.

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Abstract

Objective: In this study the effect of ethanol extract of plantain on an experimental model of anxiety in the elevated plus-maze model in rats was investigated. Materials & Methods: In this study, 42 rats in each group of 6 animals were used: 1. Extract preparation: The dried leaves of plantain plants using 70% ethanol by maceration for 72 hours, the ethanol extract obtained after evaporation of the solvent, the residue was stored in a refrigerator until use. 2. Create the experimental anxiety on the elevated plus-maze. The negative control group received normal saline and positive control group received anti-anxiety drugs (diazepam) intraperitoneally, the exposure the elevated plus-maze model of anxiety that is cross-shaped and evaluated. 3. Evaluate the effects of intraperitoneal injection of plantain leaf extract on experimental models of anxiety: The plantain leaf extract at doses of 25, 50, 100, 200 and 400 mg / kg of body weight intraperitoneally 30 min before the test was administered and its effects on the anxiety was assessed. The results of this study as Mean ± SEM and were evaluated using analysis of variance (ANOVA). Results: The results showed plantain extract at doses of 25, 100 and 200 mg/ kg of body weight significantly increased (P <0.05) in the number of entrance in open arms compared to the control group. Also, the plantain extract at 100 mg/ kg of body weight was significantly (p <0.05) increased the time spent in the open arm than the control group. Conclusion: The findings of this study suggest that the anxiolytic effects of plantain extract and this effect may be due to the antioxidant properties of flavonoids in plant stems and interaction with the GABA ergic system and strengthen its effectiveness.

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