protective effect of Amaranthus aqueous extract on liver damage induced by Carbontetrachloride in male rats

Morovatisharifabad, Majid and Salehi, Elham and Shams, Zahra protective effect of Amaranthus aqueous extract on liver damage induced by Carbontetrachloride in male rats. In: 2nd International and 6th National Iranian Congress on Organic vs. Conventional Agriculture, August 2019, Ardabil, Iran.

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Abstract

Chemical pesticides cause liver dysfunction, inflammation and necrosis of hepatocytes. The aim of this investigation was to study the protective effect of Amaranthus extract on rats treated with carbon tetrachloride.In this experimental study, 35 male rats weighting 300 g were randomly divided into 5 groups. They were: control group (normal saline 0.5 mg), sham group (0.5ml olive oil), control group (2 mg carbontetrachloride) treatment groups 1 and 2 (300 and 600 mg Amaranthus aqueous doses) Received oral extracts for 4 weeks. At the end of the experiments, blood samples were collected directly from the heart for examination of liver enzymes, and the liver tissue was stained with routine histological staining method for microscopic examination. The results of this study showed that carbontetrachloride contributes to inflammation and necrosis of the liver tissue. The groups treated with Amaranthus extract showed less inflammation than control groups.Serum liver enzymes significantly increased in the carbontetrachloride treated group compared with the control group. In Amaranthus treated groups, the liver enzymes were significantly reduced. Thus, Amaranthus extract protects the liver tissue against carbon tetrachloride.

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