Protective effects of Taraxacum erythrospermum extract on histopathological lesions of liver in mice fed with high fat diet

مروتی شریف اباد, مجید and صالحی, الهام and شمس, زهرا Protective effects of Taraxacum erythrospermum extract on histopathological lesions of liver in mice fed with high fat diet. In: 2nd International and 6th National Iranian Congress on Organic vs. Conventional Agriculture, August 2019, Ardabil, Iran.

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Abstract

Non-alcoholic fatty liver syndrome is a common outbreak in the Iranian society, which is nowadays known as the most common liver disease, and is likely to become a major public health problem in terms of health. The aim of this study was to evaluate the protective effects of Taraxacum erythrospermum extract on fatty liver caused by a high-dose diet in a model of mice. In different experimental groups, treated with dietary control, high-fat diet and high-fat diet plus Taraxacum erythrospermum extract were treated at different doses. At the end of the experimental period, tissue samples from the mice were fixed in 10% formalin buffer to assess the histopathology of the liver. The above samples were prepared with 5 micron thick histological slices. Serum levels of liver enzymes and total bilirubin for liver damage and biliary function were studied. The histopathological study of liver indicates a change in fat in the group of mice fed with high-risk diet. Taraxacum erythrospermum, depending on the dose, reduce the accumulation of fat in hepatocytes, due to the presence of saponin and the association of fat and cholesterol. Serum lipase enzyme levels in mice fed diet with high fat diet significantly increased and total protein and albumin levels decreased. significantly High doses of Taraxacum erythrospermum extract (250 and 150 mg / kg body weight) significantly increased the serum levels of liver damage markers and decreased significantly the total protein and albumin levels. However, the lower doses of Taraxacum erythrospermum (50 mg per kg body weight) could not significantly change these doses.

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