Comparision of The Effect and Maintenance of Two Equal-Volume Training Frequency and Supplement of Saffron on Cardiorespiratory Factors, in Obese Women with Type 2 Diabetes

Rajabi, Ali (2018) Comparision of The Effect and Maintenance of Two Equal-Volume Training Frequency and Supplement of Saffron on Cardiorespiratory Factors, in Obese Women with Type 2 Diabetes. Doctoral thesis, University of Mohaghegh Ardabili.

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Text (بررسی و مقایسه تاثیر و ماندگاری دو فرکانس تمرینی هم حجم و مکمل یاری زعفران بر برخی از عوامل قلبی-تنفسی زنان چاق مبتلا به دیابت نوع 2) Ali Rajabi.pdf Download (1MB) | Preview

Abstract

Purpose: The main and effective treatment for diabetes mellitus is the use of insulin and blood glucose lowering agents, Because these compounds have many adverse effects, there is a need to find new ways or effective compounds to treat diabetes with less side effects. Therefore, the present study was performed aims to investigate and compare the effect and durability of two exercise frequencies in both volume (as a new method) and supplementation of saffron (as an effective combination in the treatment of diabetes with fewer side effects) on some cardio respiratory factors in obese women with Type 2 diabetes. Methods: A total of 72 inactive obese women with type 2 diabetes mellitus who were resident of West Islamabad city in Kermanshah province (Iran), were randomly selected into 6 groups (each group 12) (1-3 sessions of exercise + supplementation, 2-6 sessions of exercise + supplementation, 3-3 practice sessions + placebo, 4-6 sessions + placebo, 5 supplements, 6-placebo). Groups 1, 2, 3, and 4 for 8 weeks (group 1 and 3 three sessions per week, and groups 2 and 4 six sessions per week aerobic training with intensity 60-75% of maximum heart rate) with the same volume. Daily dose of 400 mg of Saffron sprout powder (once a day) was used for two months. The placebo contained 400 mg of wheat flour. Blood sampling was carried out in three stages, 48 hours before and after supplementation and exercise, and two weeks after completion of exercise and supplements (period), blood sampling was done after 12 hours of fasting. In the following were evaluated Adiponectin, Ristin, Irisin, LDL-C, HDL-C, TNF-a, IL-6, and the most important metabolic parameters in type 2 diabetes, including glucose, insulin, HOMA-IR and HbA1c, spirometery indices (FVC, FEV1, PEF, MVV) and blood pressure (SBP, DBP, PP, and MAP). Data analysis was performed using repeated measure ANOVA, one-way ANOVA and one-way ANOVA with a post-test LSD. Statistical operation was performed using spss version 22 and a significant level of 5% was considered. Results: The results showed that in the post-test and survival phase, Adiponectin, Resisten, Irisin, TNF-α, IL-6, LDL-C, HDL-C, body fat percentage, BMI, glucose, insulin, HOMA-IR, HbA1c, FVC, FEV1, PEF, MVV, SBP, PP and MAP were significantly different between the 6 groups (P <0.05). Meanwhile, the highest mean change was observed at the frequency of 3 sessions of exercise + supplementation. Significantly significant differences were not significant in both post-test and survival stages in the above variables between complementary groups, 3 sessions + placebo + 6 sessions of exercise + supplementation (P> 0.05). In examining the frequency of exercise in the mentioned variables, there was a significant difference between the two frequencies in both the post-test and survival stages, but the results of the intra-group showed that significant changes were only at the frequency of 3 sessions + placebo + sessions (P<0.05). Conclusion: According to the results of this study, it can be concluded that aerobic activity and oral intake of saffron alone will have a general protective effect against the increase of the indices effective in type 2 diabetes. Additionally, the combination of these two causes a greater response to the control of these indicators and, consequently, the complications of type 2 diabetes. Also, due to the role of Irisin protein, TNF-a, IL-6 and adiponectin and resistin hormones in regulating fatty metabolism and HOMA-IR, the role of aerobic training and saffron in improving HOMA-IR and fat profile can be attributed to this Factors. Due to the fact that the most effective spirometery indices in assessing the respiratory state of diabetic patients (FVC, FEV1), the reason for increasing these variables in saffron supplementary groups is booster due to 1-increase arterial oxygen-2-increase of oxygen release In plasma or increase in the rate of absorption of oxygen by saffron; the increase in these variables in the groups that perform the frequency of aerobic training can be due to reduced fat content and improve the performance of respiratory muscles, although the performance of respiratory muscles was not investigated in this study. Also, due to weight loss and lipid profiles following 8 weeks of aerobic training, it is likely that SBP reduction will be achieved only in the aerobic exercise frequency of the present study. Also, reduction of SBP in saffron supplements can be due to inhibition of sympathetic system, ganglion block and inhibition of angiotensin converting enzyme. Of course, there is a possibility that the effect of reducing blood pressure by saffron is due to vasodilator effects of the arteries or the effect on some ionic channels such as calcium or on some endogenous materials such as nitric oxide or some prostaglandins, such as PGI2. Regarding exercise frequencies, it can be concluded that long-term aerobic exercises (in each training session), like the frequency program of 3 sessions per week, in the present study, have better effects than less exercises (in a training session), such as the 6-session frequency program A week's workout is to improve or control the side effects of type 2 diabetes. Keywords: Obesity Type 2 Diabetes, Aerobic Exercise Frequency, Saffron, Effective Indicators of Type 2 Diabetes, Lipid Profile, Spirometery, Blood Pressure

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