Effects of Acute and Chronic Aerobic Exercise Training on Vascular and Systemic Inflammatory Biomarkers in Coronary Artery Patients After Revascularization Interventions

Basati, Fatemeh (2018) Effects of Acute and Chronic Aerobic Exercise Training on Vascular and Systemic Inflammatory Biomarkers in Coronary Artery Patients After Revascularization Interventions. Doctoral thesis, University of Mohaghegh Ardabili.

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Text (اثرات حاد و مزمن فعالیت ورزشی هوازی بر شاخص های التهاب عروقی و سیستمیک در بیماران عروق کرونری بعد از مداخلات ریوسکولاریزاسیون) Fatemeh Basati.pdf Download (1MB) | Preview

Abstract

Aims and background: Inflammatory biomarkers such as pentraxin-3(PTX3), Vascular cell adhesion molecule-1(VCAM-1) and C-reactive protein(CRP) increased because of inflammatory disease like atherosclerosis. Studies showed that these biomarkers are predictor of cardiovascular disease, also exercise-based cardiac rehabilitation has anti-inflammatory effects. In this study we examined acute and chronic effects of aerobic exercise training on PTX3, VCAM-1 and CRP in patients with coronary artery disease after revascularization intervention. Methods: 65 male patients with coronary artery disease participated in this study. Subjects underwent percutaneous coronary intervention(PCI) and Coronary artery bypass grafting(CABG) and dedicate in intervention group (IG; n=35, age: 58.31±7.21 years) and control group (CG; n= 30, age: 57.9±7.4 years). Patients in IG performed acute aerobic exercise session (15 min warm up, 30 min running or waking on treadmill at 70% maximal heart rate and 10 min cool down) and 8 weeks cardiac rehabilitation program (CRP) at 70 % of maximum heart rate, 3-4 times a week each session 60 min supervised by medical staff, CG has no physical activity program. Heart rate obtained form standard limited exercise test based on Bruce protocol. Blood was drawn before and 30 min after acute aeobic exercise session and 24 after 8 weeks aerobic exercise to measure plasma levels of PTX3, VCAM-1 and CRP. For CG blood samples collected before and after 8 weeks aerobic exercise. Results: our results showed that after acute aerobic exercise session plasma levels of VCAM-1(558±207ng/ml vs 633±138 ng/ml, p≤0.049) and CRP(3.32±1.87 vs 3.88±2.27 mg/L, p≤0.037) incresed significantly. There is no significant differences between plasma levels of PTX3 after acute aerobic exercise. one way Anova showed no significant differences in plasma concentration in VCAM-1, PTX3 and CRP between PCI and CABG patients. After 8 weeks of exercise-based cardiac rehabilitation plasma levels of PTX3, CRP and VCAM-1 in IG were significantly lower than CG group, there is no significant differences in inflammatory responses to exercise-based cardiac rehabilitation between PCI and CABG patients. Conclusion: the results of this study showed that acute aerobic exercise acts as an stressor and leading to activation of immune responses and increased systemic and vascular inflammatory biomarkers. But prolonged aerobic exercise for 8 weeks can decrease these biomarkers in CAD patients after revscularization interventions. it should be noted that type of operation has no effect on inflammatory response to acute and chronic exercise. key words: pentraxin 3, adhesion molecules, C-reactive protien, aerobic exercise training

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