Study of Silymarins environmental effects on visceral pain and its relationship with the histaminergic system in Wistar rats

Aidin, Esmaeil and Behmaram, Reza and Mojtahedin, Ali and Shakoori, Merdarush and Seyed Sharifi, Reza (2016) Study of Silymarins environmental effects on visceral pain and its relationship with the histaminergic system in Wistar rats. Masters thesis, University of Mohaghegh Ardabili.

Text (مطالعه اثرات محیطی سیلی¬ مارین بر درد احشایی و ارتباط آن با سیستم هیستامینرژیک در رت-های نژاد ویستار) Esmaeil Aidin.pdf Download (387kB)

Abstract

The pain is usually "a tissue or damage to the tissue due to the destruction caused by triggers chemical, thermal, mechanical and electrical occur in two forms: acute and chronic updated and motivation in each case can be used as a factor limiting or disabling them from daily activities. traditional medicine and medicinal plants are a good source for finding analgesic drugs. Therefore, the role of medicinal plants thistle on visceral pain experience using visceral pain in adult male Wistar rats were studied. In this study, 54 male Wistar rats were used for grouping. Group 1: Control, normal saline intraperitoneally and then injected with acetic acid percent intraperitoneally, groups 2, 3, 4 and 5 respectively receiving different doses of silymarin (50, 100, 200 and 400 mg kg body) intraperitoneally and 30 minutes later intraperitoneally injected with acetic acid percent, group 6 received 20 mg of chlorpheniramine kg intraperitoneally and 30 minutes later, acetic acid intraperitoneally Group 7: receiving 20 mg to kg of ranitidine intraperitoneally and 30 minutes Bdasyd Stick to intraperitoneally, Group 8: receiving the 20 mg chlorpheniramine intraperitoneally and 30 minutes later 100 mg to kg of silymarin to intraperitoneally and again "30 minutes of acetic acid a percentage of the value of a mill intraperitoneally, group 9: receiving the 20 mg ranitidine intraperitoneally and 30 minutes later 100 mg to kg silymarins intraperitoneally and again "30 minutes of acetic acid intraperitoneally a percentage of the value of a millThe results showed that intraperitoneal injection of acetic acid significantly (P <0.05)causes pain in animals. Intraperitoneal injection of silymarin also mentioned at all doses reduces pain, but the amount of 100 mg kg body weight analgesia created the greatest impact. The Pretreatment with 20 mg kg of body weight to silymarin (100 mg kg) significantly decreased (P <0.05) response was visceral pain. On the other hand, pretreatment with ranitidine 20 mg kg body weight before administration of silymarin (100 mg kg) significantly decreased (P <0.05) Response was visceral pain. Given that silymarin is a combination of flavonoids, flavonoids by inhibiting the enzyme cyclo someone salinity, the production of prostaglandins from arachidonic acid in response to inflammatory stimuli inhibited. Since prostaglandins in inflammation and pain exacerbated effects and originate from arachidonic acid, as well as anti-inflammatory substances such as histamine are released in the environment, it seems likely "Flanvyydhay in Silybum marianum with interaction

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